Your best Pass Blocker should be LT
Your best Run Blocker should be RT
Your Fastest Run Blocker should be LG
Your Strongest Pass Blocker should be RG
Your best INT, DIS OL-man should be C
Reasons
LT = pass protection. The better the protection, the better chances of completing a pass
LG = Pass protection is a plus, but most successful runs are to the left side. Need to have someone get to the second layer of LBs and DEs to seal that extra yard.
C = The QB of the OL. Needs your smartest and best disciplined, as well as your best all-around PB/RB OL
RG = Many Teams like to match their best Pass Rushing Ends against opposing Teams RT (Strong RB but weak PB). Having a strong PB OL at this position can assist in delaying the DE from reaching the QB