For play selection strategy. One can look at the presnap alignment and assignments.
For running the ball. Specifically the right defensive tackle as he is shaded towards the center leaving a large hole to his right. Play over use is going to change the results but running at that gap off the left shoulder of the left guard is the defenses weak point.
Passing is trickier due to the fact base defenses (ones with no blitzes) are not calculated for the overuse penalty, which is actually a ratings boost for the other teams skill ratings.
The outside linebackers drop at angle into the hook zone…. pending it’s a quicker pass. 4.6 has some effective offensive plays that are such but these OLBs take away from hitches, slants, outs and even deep posts with maximum effect .
But here I would look at the responsibilities of the cover guys and With the OLBs acting as safeties the weak spot is over the middle. But the key it to clear that middle linebacker out.
And you do that by noting his assignment which is wr5. In a 2-1-2 that would be the FB. Say it was a 3 wr set with two backs it also would be the FB who would to be going out into the flats. He is the one to open up the middle of the field for another receiver who is going to be the actual target where the MLB once was.
Noting the names of the offensive play along with the distance of the routes denotes the primary and secondary receivers. Still randomness is thrown in to there by the code but one can “work” OLB zone flats. It’s just tough do to the because of how tough passing is in general.